Bibliography By Topic

ANTI-INFLAMMATORY PROPERTIES

Davis, Robert H. (PhD), Di Donato, Joseph J. (BA, BS), Hartman, Glenn M. (BS), & Haas, Richard C. (BA). (1992). Mannose-6-phosphate: Anti-inflammatory and activity of a growth substance in Aloe vera. Submitted for 1993 William J. Stickle Award.

Abstract: This study attempts to define the role of the two major sugar constituents in the Aloe plant, mannose and glucose. We analyzed these sugars in the phosphorylated form. The significance of this study lies in the ability of the phosphorylated sugars to fit the growth factor receptors on the surface of the fibroblast.

Davis, Robert H. (PhD), Parker, William L. (BA), & Merdock, Douglas P. (Bsc). (1991, January). Aloe vera as a biologically active vehicle for hydrocortisone acetate. Submitted for the 1989 William J. Stickel Awards.

Abstract: This study attempts to use Aloe vera with hydrocortisone acetate to improve the effectiveness of this type of therapy. Inflammation is a major component of many of the conditions treated by the podiatrist. The significance of this study lies in the ability to increase steroid potency by using a natural substance.

Davis, Robert H. (PhD), Di Donato, Joseph J. (BA, BS), Hartman, Glenn M. (BS), & Haas, Richard C. (BA). (1994, February). Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. Journal of the American Podiatric Medical Association, 84(2), 77-81.

Abstract: Aloe vera improves wound healing and inhibits inflammation. Since mannose-6-phosphate is the major sugar in the Aloe gel, the authors examined the possibility of its being an active growth substance. Mice receiving 300 mc/kg of mannose-6-phosphate had improved wound healing over saline controls. This dose also had anti-inflammatory activity. The function of mannose-6-phosphate in A. vera is discussed.

Davis, Robert H. (PhD), Rosenthal, Kenneth Y., Cesario, Linda R., & Rouw, Gregory A. (1989, August). Processed Aloe vera administered topically inhibits inflammation. Journal of the American Podiatric Medical Association,79(8), 395-397.

Abstract: Aloe vera preparations were evaluated for topical anti-inflammatory activity using the croton oil-induced edema assay. These results may be used as a baseline to assess the biologic activity of A. vera in the treatment of inflammation by podiatric physicians.

Davis, Robert H. (PhD), Leitner, Mark G. (RPh), & Russo, Joseph M. (BA). (1987, November). Topical anti-inflammatory activity of Aloe vera as measured by ear swelling. Journal of the American Podiatric Medical Association, 77(11), 610-612.

Abstract: The authors believe that this study provides a major breakthrough for Aloe and an effective treatment against inflammation for podiatrists.

Davis, Robert H. (PhD), Shipiro, Eugene, & Agnew, Patrick S. (1985, May). Topical effect of Aloe with ribonucleic acid and vitamin C on adjuvant arthritis. Journal of the American Podiatry Association, 75(5), 229-237.

Abstract: The anti-inflammatory and anti-arthritic topical activity of combined ascorbic acid, aloe extract, and RNA in hydrophilic cream were evaluated in this study. The results may provide an effective topical treatment for rheumatoid arthritis.

Fujita, Keisuke, Suzuki, I., Ochiai, J., Shinpo, J., Inoue, S., & Saito, H. (1978). Specific reaction of Aloe extract with serum proteins of various animals. Experientia,34, 523-524.

Abstract: This report details a very interesting approach to explain the effectiveness of Aloe on healing wounds and being anti-inflammatory. They found that there were some biologically active proteins contained in Aloe and that these may be involved in the healing process.

Fujita, Keisuke, Teradaira, Ryon, & Nagatsu, Toshiharu. (1976). Bradykinase activity of Aloe extract. Biochemical Pharmacology, 25, 205.

Abstract: As pharmacological evidence for the anti-inflammatory action of aloe, we have found that aloe extract contains bradykinase activity.

Furta, Keisuke, & Teradaira, Ryon. (N.D.). Bradykinase activity of Aloe extract. In Aloe Vera: New Scientific Discoveries by Max B. Skousen, 61-63.

Abstract: Technical report from Japanese source. The paper deals with the anti-inflammatory activity of Aloe vera and shows a very encouraging indication for reducing inflammation in wounds.

Jia, Qi (Dr.). Research focuses on chromones in Aloe. Univera Pharmaceuticals, Inc.

Abstract: Dr. Qi Jia of Univera Pharmaceuticals investigates the role chromones may play in the anti-inflammatory effects Aloe displays.

Obata, Masafumi, Ito, Shosuke, Beppu, Hidehiko, Fujita, Keisuka, & Nagatsu, Toshiharu. (N.D.). Mechanism of anti-inflammatory and anti-thermal burn action of Aloe arborescens Mill. var. natalensis Berger. Fujita Health University, Japan, 19-28.

Abstract: Carboxypeptidase (Cpase) was partially purified from Kidachi aloe (Aloe Arborescens Mill. var natalensis Berger) by FPLC system, and was administered intravenously to female ICR mice with inflammation. The enzyme preparation revealed significant effects on alleviation of pain and inhibition of vascular permeability in abdominal region. It also revealed an anti-thermal burn action on rat's hind paws, when it was administered to female Wister rat intravenously.

Sarkar, D., Dutta, A., Das, M., Sarkar K., Mandal, C., Chatterjee, M. (2005, November 1). Effect of Aloe vera on nitric oxide production by macrophages during inflammation. Indian Journal of Pharmacology.

Abstract: AVL possesses acute and chronic anti-inflammatory activity, which is partly mediated by reduced production of NO, which in turn prevents the release of inflammatory mediators.

Tizard, Ian (Dr.). (N.D.). Aloe-derived carbohydrates reduce inflammation by blocking neutrophil emigration mediated by certain beta integrins. Texas A&M University, Consultant for Carrington Laboratories.

Abstract: This abstract presented by Dr. Ian Tizard of Texas A&M University reveals the effects Aloe has on inflammation.

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