Bibliography By Topic

WOUND / FRACTURE HEALING

Chithra, P., Sajithlal, G.B., & Chandrakasan, Gowri. (1998, January). Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats. Journal of Ethnopharmacology,59(3), 179-186.

Abstract: It was observed that Aloe vera increased the collagen content of the granulation tissue, as well as its degree of cross linking as seen by increased aldehyde and decreased acid solubility. The group consuming Aloe vera indicated enhanced levels of type III collagen.

Davis, Robert H. (PhD), Di Donato, Joseph J. (BA, BS), Hartman, Glenn M. (BS), & Haas, Richard C. (BA). (1992). Mannose-6-phosphate: Anti-inflammatory and activity of a growth substance in Aloe vera. Submitted for 1993 William J. Stickle Award.

Abstract: This study attempts to define the role of the two major sugar constituents in the Aloe plant, mannose and glucose. We analyzed these sugars in the phosphorylated form. The significance of this study lies in the ability of the phosphorylated sugars to fit the growth factor receptors on the surface of the fibroblast.

Davis, Robert H. (PhD), Kabbani, Joseph M. (BS), & Maro, Nicholas P. (BS). (1987, April). Aloe vera and wound healing. Journal of the American Podiatric Medical Association, 77(4), 165-169.

Abstract: The authors present a study of the wound healing effects of Aloe vera. Special emphasis is given to combined RNA and vitamin C with Aloe because of their effectiveness against arthritis. Consideration is given to anthraquinones because their influence is not clearly understood. As a result of the preliminary findings in the study, the authors recommend Aloe for the treatment of wounds.

Davis, Robert H. (PhD), Leitner, Mark G. (RPh, DPM), Russo, Joseph M. (DPM), & Byrne, Megan E. (BS). (1989, November). Wound healing: Oral and topical activity of Aloe vera. Journal of the American Podiatric Medical Association, 79(11), 559-562.

Abstract: The influence of Aloe vera, orally and topically, on wound healing was studied. These data suggest that A. vera is effective by both oral and topical routes of administration.

Farkas, Alexander (Dr.). (1963). Topical medicament including polyuronide derived from Aloe. Chemical Abstracts, 60, 378g-379a. Patent on one of the active ingredients of Aloe vera, U.S. Patent No. 3,103,466, received on September 10, 1963. Claim was filed on December 23, 1954.

Abstract: The product, while quickly relieving pain, particularly from burns, appears thereby to have an analgesic and anesthetic effect; particularly in the type of healing rapidly promoted by the composition, it appears to have a detoxifying effect that may be the results of the reducing action inherent in the polyuronide without causing irritation, because burns, even second and third degree burns, become healed unusually rapidly, and the skin re-forms with rapid granulating, without scab formation.

Fox, Timothy R. (1990, December). Aloe vera: Revered, mysterious healer. Health Foods Business, 45ff.

Abstract: Part of a Consumer Education Series. Discusses the ability to quickly and completely heal skin tissue.

Fujita, Keisuke, Suzuki, I., Ochiai, J., Shinpo, J., Inoue, S., & Saito, H. (1978). Specific reaction of Aloe extract with serum proteins of various animals. Experientia,34, 523-524.

Abstract: This report details a very interesting approach to explain the effectiveness of Aloe on healing wounds and being anti-inflammatory. They found that there were some biologically active proteins contained in Aloe and that these may be involved in the healing process.

Furta, Keisuke, & Teradaira, Ryon. (N.D.). Bradykinase activity of Aloe extract. In Aloe Vera: New Scientific Discoveries by Max B. Skousen, 61-63.

Abstract: Technical report from Japanese source. The paper deals with the anti-inflammatory activity of Aloe vera and shows a very encouraging indication for reducing inflammation in wounds.

Goff, Sidney (PhD), & Levenstein, Irving (PhD). (1964). Measuring the effects of topical preparations upon the healing of skin wounds. Journal of the Society of Cosmetic Chemists, 15, 509-518.

Abstract: Under controlled conditions, with the mouse as the experimental animal, it has been shown that the tensile strength of a standardized skin wound increased as the wound healed. The effects of several preparations applied topically to the standard wound were demonstrated by tensile strength measurements.

Ivy Research. (1978, October-December). Wound Healing Assay, Ivy Research Protocol #3791.

Abstract: To determine whether the materials tested interfere or enhance the healing process of superficial dermal wounds.

Miller, Alan L. (2003, November 1). Nutritional support for wound healing. Alternative Medicine Review.

Abstract: Discusses wound healing with nutritionals including Aloe vera. Includes a large list of references.

Moore, Timothy E. (DDS/MS, PC). Aloe vera: Its potential use in wound healing and disease control in oral conditions.

Abstract: Highlights eight ways Aloe vera is being used in dentistry.

ProQuest Information and Learning Company. (2004, July 27). Aloe fluid aids survival from blood loss. United Press International.

Abstract: A resuscitation fluid from Aloe vera might save the lives of patients suffering massive blood loss caused by trauma.

Republic Hospital, Baturni, Russia. (1960). Preserved Aloe juice as hemostatic agent following tonsillectomy. Vestn. Oto-tino-laring,3, 99.

Abstract: A good hemostatic effect is noted, followed by fairly rapid healing of the tonsillary niches.

Robson, Martin C. (MD), Jellema, Aileen (RN), Heggers, John P. (PhD), & Hagstrom, William J. (MD). (1980, March 27-29). Care of the healed wound: A prospective randomized study. Twelfth Annual Meeting Report, American Burn Association, San Antonio, Texas, 94-95.

Abstract: Clinical study of Aloe being used on humans, but only after the burn's wounds had completed the first stages of healing and then Aloe was tested in the prevention of infection in the treatment of new scars. In this case, Aloe was as good as penicillin, thus also enhancing healing and reducing complications. This is a very favorable comparison, especially when the negative side effects penicillin sometimes produces are taken into consideration.

Shermetov, S. G., & Usikov, V. N. (N.D.). Influence of subcutaneous injections of Aloe extract upon the healing of bone fractures. In Aloe Vera: New Scientific Discoveries by Max B. Skousen, 112-113.

Abstract: Biostimulants, especially aloe extract, that are liable to potentiate the physiological functions of the organism, contribute to mobilization of calcium and inorganic phosphorus from the mineral depot into the blood and to the fractured bone. Aloe extract is found to have reduced the consolidation terms of fractures by 20-25 days.

Smith, Sheri (Dr.). Hydrogel dressings offer advancements in wound healing. Irving, TX: Carrington Laboratories.

Abstract: This abstract from Dr. Sheri Smith of Carrington Laboratories discusses the use of hydrogel dressings in wound care.

Unknown. (1998, July). How Aloe heals. Nutrition Science News.

Abstract: The authors speculate that aloe gel might accelerate wound healing by lowering blood glucose levels (shown to improve wound healing in diabetics) or by stimulating the function of fibroblasts, the cells that make collagen.

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